MAKING WAVES
Press Releases
FirstWave Bio to Initiate Phase 2a/2b Study of FW-1022, a Proprietary Form of Niclosamide, to Treat COVID-19
Proprietary formulation of approved antiviral medicine targets viral “reservoir” in the gut believed responsible for prolonged…
Presentations & Publications
The field of immune metabolism is advancing rapidly. We are building on – and contributing to – a growing body of scientific literature.
2020
Shin, B., Benavides, G. A., Geng, J., Koralov, S. B., Hu, H., Darley-Usmar, V. M., & Harrington, L. E. (2020). Mitochondrial oxidative phosphorylation regulates the fate decision between pathogenic Th17 and regulatory T cells. Cell Reports, 30(6), 1898-1909. doi:10.1016/j.celrep.2020.01.022. Read more.
2019
Fuseini, H., Cephus, J., Wu, P., Davis, J. B., Contreras, D. C., Gandhi, V. D., Rathmell, J. C., & Newcomb, D. C. (2019). ERα signaling increased IL-17A production in Th17 cells by upregulating IL-23R expression, mitochondrial respiration, and proliferation. Frontiers in Immunology, 10. doi:10.3389/fimmu.2019.02740. Read more.
Kaufmann, U., Kahlfuss, S., Yang, J., Ivanova, E., Koralov, S. B., & Feske, S. (2019). Calcium Signaling Controls Pathogenic Th17 Cell-Mediated Inflammation by Regulating Mitochondrial Function. Cell Metabolism, 29(5), 1104-1118. doi:10.1016/j.cmet.2019.01.019. Read more.
2017
Franchi, L., Monteleone, I., Hao, L., Spahr, M. A., Zhao, W., Liu, X., Demock, K., Kulkarni, A., Lesch, C. A., Sanchez, B., Carter, L., Marafini, I., Hu, X., Mashadova, O., Yuan, M., Asara, J. M., Singh, H., Lyssiotis, C. A., Monteleone, G., Opipari, A. W., & Glick, G. D. (2017). Inhibiting oxidative phosphorylation in vivo restrains Th17 effector responses and ameliorates murine colitis. The Journal of Immunology, 204(2). doi:10.4049/jimmunol.1600810. Read more
2014
Tao, H., Zhang, Y., Zeng, X., Shulman, G. I., & Jin, S. (2014). Niclosamide ethanolamine improves blood glycemic control and reduces hepatic steatosis in mice. Nature Medicine, 20(11), 1263-1269. doi:10.1038/nm.3699. Read more